The Oxford Nanopore Technologies, a spin-out company from the University of Oxford, announced that it will unveil DNA Strand sequencing at the Advances in Genome Biology and Technology (AGBT) conference in Marco Island, Florida on 17th Feb and will commercialize the Strand sequencing technology within 2012.
The Oxford Nanopore Technogies’ CTO Clive G Brown, will present a talk titled “Single Molecule ‘Strand’ Sequencing Using Protein Nanopores and Scalable Electronic Devices”. at the 2012 AGBT conference. And at the talk Oxford Nanopore will show off data from DNA strand sequencing and its work on electronics-based sensing devices.
DNA Strand Sequencing Using Bio-Nanopores
The idea behind Oxford Nanopore’s DNA ‘strand sequencing’ technology is novel and easy understand. The technology uses a protein nanopore that has a hole just right enough for a DNA strand to pass through. Oxford Nanopore has developed technologies that can identify individual DNA bases on the strand as the DNA passes through the nanopore.
As a DNA strand moves along, Oxford Nanopore sequences the identified nucleotide bases. Needless to say implementing these steps to sequence correctly and fast is challenging. Oxford Nanopore highlights that the major challenges in strand sequencing include
- controlled translocation of the strand through the nanopore
- identifying and sequencing individual bases correctly, as a DNA polymer passes through a nanopore, a number of individual DNA bases occupy the aperture of the nanopore at any time.
In addition to DNA strand sequencing method, the company is also developing Exonuclease sequencing that uses a protein nanopore.
Oxford Nanopore was founded in 2005 by Professor Hagan Bayley of the University of Oxford. In 2008, it started working on commercializing the technologies from nanopore research laboratories at Harvard and University of California Santa Cruz. Learn more about Oxford Nanopore Technologies DNA strand sequencing from its educational video.