Evolution of Next-Gen Sequencing Development

Lex Nederbragt from University of Oslo has a blog post on visualizing the development of Next-gen sequencing capabilities by different technologies.  There are already 27 sequencers from 6 companies.

Illumina leads the pack with nine sequencer variations since it acquired Solexa.  Illumina’s read length has gone from 25 to 250 bases in about six years.  Illumina also leads in the amount of sequence data produced per run; Illumina’s GA, launched in 2008, first touched the 1GB per sequencing run milestone and with latest HiSeq Illumina can produce 600GB of data per run.  Solid 1 which hit the 1GB data per run in 2007, has gone up to 180 GB with the latest Solid 5500xl.

@lexnederbragt also posted the data used in the blog post on figshare as text file. Here is the data in a web-friendly tabular form.

Next-Gen Sequencing Evolution

PlatformInstrumentYearReads per runRead lengthBases per run (gigabases)
ABI Sanger3730xl-968000.0000768
454GS2020052000001000.02
454GS FLX2007400000250.1
454GS FLX Titanium 200910000005000.45
454GS FLX+201110000007000.5
IonTorrentPGM 314 chip2011 100000 1000.01
IonTorrentPGM 316 chip 2011 1000000 100 0.1
IonTorrentPGM 318 chip 20115000000 100 0.5
IonTorrentPGM 318 20125000000 200 1
IonTorrentProton2012 50000000 200 10
Illumina GA (launch?) 2006 28000000 25 0.7
IlluminaGA 2008 28000000 351
Illumina
GA IIND 100000000 50 5
IlluminaGAIIx 2009 440000000 75 33
IlluminaGAIIx2011 6400000007548
IlluminaHiSeq20102000000000100200
IlluminaHiSeq 2011 3000000000 100 600
Illumina MiSeq2011
30000000 150 4.5
IlluminaMiSeq 2012300000002508.5
SOLiD 1 2007 40000000 25 1
SOLiD 2 2008 115000000
354
SOLiD3ND 320000000 50
16
SOLiD 4 ND 200000000050100
SOLiD 5500xl2011
300000000060 180
PacBioRS C120113600013000.045
PacBio RS C2
2012360002500 0.090
PacBioRS C2 XL 2012 36000 4300
0.155

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