Storified tweets from Oxford Nanopore’s technology focus Google hangout by Clive Brown. Briefly,
- Oxford Nanopore revealed the pore it uses in its devices. It is not MSP pore. :) It is using CsgG pore from E.coli. And it is using heavily engineered CsgG with over 700 mutations (with license) to make it a better pore for sequencing. Immediately after the update meeting, VIB/Vrije Universiteit Brussels announced that VIB’s Han Remaut has teamed up with Oxford Nanopore Technologies for the development of nanopore sensing technology. Han Remaut group has been working on work on the protein nanopore, CsgG and will be in ‘R9’ in the MinION handheld DNA sequencer and the PromethIONTM system.
- Oxford nanopore is seeing a big improvement in accuracy with R9 and new base caller. 85% accuracy in 1D and 95% accuracy in 2D. And Oxford nanopore is moving away from the current HMM-based base caller to Neural Network based base caller.
- March-April is pretty hectic for Nanopore, with lots of releases from Oxford Nanopore including the release of source code for base calling, Developmental R9, and first shipping of Promethion device.
Watch the Google hangout recording at You Tube.