Clive Brown’s Talk at London Calling 2017 #nanoporeconf

GridION x5

GridION x5

London Calling, the two day annual conference on all things Nanopore is happening right now. Among the interesting talks, Clive Brown, Oxford Nanopore’s CTO gave a talk titled “Some mundane and incremental types”. The title is the winner for the most understated title in ultra-hyped world. Thanks to tonnes of live tweeters from “London Calling 2017” event, here is the storified version of Clive Brown’s talk.

PromethION Model Evolution

PromethION Model Evolution

If you don’t have time to go through all the tweets. Here is a short summary of Clive Brown’s Talk.

  • Sequencing entire chromosomes using @nanopore is a month to a year away
  • 4,500 MinIONs are “in the wild”
  • GridION’s onboard compute will allow for real time onboard analysis like Read Until and it is  simpler than multiple laptops
  • first GridION x5 ships on 15th May
  • Two pricing models for GridION x5; $14.95 per 20GB at 2020GB flowcell with $125,000 upfront capital and $23.75 per 20GB with no upfront purchase
  • Oxford Nanopore can make 1k GridION/year.
  • PromethION in field testing is going slower. Oxford Nanopore still need some debugging to do in PromethION flowcell, 1Gbp/hr per flowcell;4 day runs
  • Future PromethION will come with compute box with FPGA for local base calling.
  • PromethION Beta system in Q4 2017 – aiming for 4.8Tb
  • For MinION, expect soon to get gains of 20-30% and most people reach ~20GB/run
  • new method 1D^2 boosts accuracy, but 1D-like simple library prep and no more 2D.
  • R9.5 out next week
  • Oxford Nanopore announced a New device ,”unanmed yet”. A dongle for real time base caller and can be easily run for MinION. Expected to be available before the end of the summer.
  • Flongle=Flow Cell Dongle will be available by the end of the year.

Also check out the awesome blog coverage from @omicsomicsblog and @coregenomic

 

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