How Replicates Can Help With Experimental Sources of Errors in Next-gen sequencing?




Nature Review Genetics has just published a nice review on how replicates (biological) in sequencing experiments are useful in finding and correcting errors. The role of replicates for error mitigation in next-generation sequencing by Kimberly Robasky, Nathan E. Lewis & George M. Church More specifically, the paper delves into sources of errors in sequencing, argues how multiple types of replicates can […]

NIH Awards $25 Million to Study Newborn Genome Sequencing in Healthcare




NIH has funded four pilot projects to study how genome and exome sequencing can help improve newborn health care. The $25 million fund from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Human Genome Research Institute (NHGRI) will support four research groups in US for 5 years. The awarded projects […]

NIH Grants: $27M for Sequencing in Patient Care and $96M for Big Data Centers for Excellence




NIH announced that it has awarded four grants for up to four years  to explore the use of whole genome sequencing to patient care. multidisciplinary research teams to explore the use of genome sequencing in medical care. The new grants are part of the National Human Genome Research Institute’s (NHGRI) Clinical Sequencing Exploratory Research (CSER) program […]

Evolution of Next-Gen Sequencing Development




Lex Nederbragt from University of Oslo has a blog post on visualizing the development of Next-gen sequencing capabilities by different technologies.  There are already 27 sequencers from 6 companies. Illumina leads the pack with nine sequencer variations since it acquired Solexa.  Illumina’s read length has gone from 25 to 250 bases in about six years. […]

Did You Know There Are (At Least) 20 Applications of Next-generation DNA Sequencing?




Just a while ago large-scale DNA sequencing meant basically sequencing DNA to assemble a genome. The low cost Next-gen sequencing technology revolution has completely changed the landscape of applications of sequencing. Even then, for most of us the applications of next-gen sequencing that stands out is Exome-sequencing, Whole Genome Sequencing, mRNA sequencing, and ChIP-Seq. Did […]